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Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial

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posted on 2023-05-19, 19:30 authored by Zheng, S, Wang, B, Han, W, Zhu, Z, Wang, X, Jin, X, Benny Eathakkattu AntonyBenny Eathakkattu Antony, Cicuttini, F, Wluka, A, Tania WinzenbergTania Winzenberg, Dawn AitkenDawn Aitken, Christopher BlizzardChristopher Blizzard, Graeme JonesGraeme Jones, Chang-Hai DingChang-Hai Ding
The aim of this study was to determine whether vitamin D supplementation and maintaining vitamin D sufficiency are associated with changes in inflammatory and metabolic biomarkers in patients with knee osteoarthritis (OA) and vitamin D deficiency. A total of 413 participants with symptomatic knee OA and vitamin D deficiency were enrolled in a randomised, placebo-controlled trial and received 1·25 mg vitamin D3 or placebo monthly for 24 months across two sites. In this post hoc analysis, 200 participants from one site (ninety-four from the placebo group and 106 from the vitamin D group; mean age 63·1 (SD 7·3) years, 53·3% women) were randomly selected for measurement of serum levels of inflammatory and metabolic biomarkers at baseline and 24 months using immunoassays. In addition, participants were classified into two groups according to serum 25-hydroxyvitamin D (25(OH)D) levels at months 3 and 24: (1) not consistently sufficient (25(OH)D≤50 nmol/l at either month 3 or 24, n 61), and (2) consistently sufficient (25(OH)D >50 nmol/l at both months 3 and 24, n 139). Compared with placebo, vitamin D supplementation had no significant effect on change in serum high-sensitive C-reactive protein, IL-6, IL-8, IL-10, leptin, adiponectin, resistin, adipsin and apelin. Being consistently vitamin D sufficient over 2 years was also not associated with changes in these biomarkers compared with not being consistently sufficient. Vitamin D supplementation and maintaining vitamin D sufficiency did not alter serum levels of inflammatory and metabolic biomarkers over 2 years in knee OA patients who were vitamin D insufficient, suggesting that they may not affect systemic inflammation in knee OA patients.


Publication title

British Journal of Nutrition








Menzies Institute for Medical Research


C A B I Publishing

Place of publication

C/O Publishing Division, Wallingford, England, Oxon, Ox10 8De

Rights statement

Copyright 2018 The Authors

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  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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