University of Tasmania
Browse

Voluntary exercise decreases atherosclerosis in nephrectomised ApoE knockout mice

Download (657.96 kB)
journal contribution
posted on 2023-05-18, 09:00 authored by Shing, CM, Fassett, RG, Peake, JM, Coombes, JS
Cardiovascular disease is the main cause of morbidity and mortality in patients with kidney disease. The effectiveness of exercise for cardiovascular disease that is accelerated by the presence of chronic kidney disease remains unknown. The present study utilized apolipoprotein E knockout mice with 5/6 nephrectomy as a model of combined kidney disease and cardiovascular disease to investigate the effect of exercise on aortic plaque formation, vascular function and systemic inflammation. Animals were randomly assigned to nephrectomy or control and then to either voluntary wheel running exercise or sedentary. Following 12-weeks, aortic plaque area was significantly (p < 0.05, d = 1.2) lower in exercising nephrectomised mice compared to sedentary nephrectomised mice. There was a strong, negative correlation between average distance run each week and plaque area in nephrectomised and control mice (r = –0.76, p = 0.048 and r = –0.73, p = 0.062; respectively). In vitro aortic contraction and endothelial-independent and endothelial-dependent relaxation were not influenced by exercise (p > 0.05). Nephrectomy increased IL-6 and TNF-α concentrations compared with control mice (p < 0.001 and p < 0.05, respectively), while levels of IL-10, MCP-1 and MIP-1α were not significantly influenced by nephrectomy or voluntary exercise (p > 0.05). Exercise was an effective non-pharmacologic approach to slow cardiovascular disease in the presence of kidney disease in the apolipoprotein E knockout mouse.

History

Publication title

PLoS One

Volume

10

Article number

e0120287

Number

e0120287

Pagination

1-12

ISSN

1932-6203

Department/School

School of Nursing

Publisher

Public Library of Science

Place of publication

United States

Rights statement

Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC