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Which is the safest NSAID for patients at elevated cardiovascular risk?
journal contribution
posted on 2023-05-21, 20:18 authored by Luke BereznickiLuke Bereznicki, Shane JacksonShane Jackson, Gregory PetersonGregory PetersonThe issue of the cardiovascular risk associated with non-steroidal antiinflammatory drugs (NSAIDs) intensified recenty with the release of a systematic review of observational studies questioning the safety of diclofenac, a non-selective NSAID. In fact, this review demonstrated an increased cardiovascular risk for rofecoxib, diclofenac, meloxicam and indomethacin; a neutral effect was shown with celecoxib, naproxen and ibuprofen (although the lower bound of the 95% confidence interval for the latter approached, which is less than reassuring). Observational studies are limited in that they are generally based on the prescription of drugs via health care providers; this makes it difficult to discern what dosages have actually been taken, and whether subjects have used over-the-counter NSAIDs or concomitant low-dose aspirin.
History
Publication title
Australian PharmacistVolume
25Issue
11Pagination
853ISSN
0728-4632Department/School
School of Pharmacy and PharmacologyPublisher
Pharmaceutical Society of AustraliaPlace of publication
Canberra, AustraliaRepository Status
- Restricted