Work productivity trajectories of Australians living with multiple sclerosis: A group-based modelling approach

<p><strong>Background: </strong>Studies have documented reduced work capacity and work productivity loss in multiple sclerosis (MS). Little is known about the longitudinal trajectories of work productivity in MS.</p> <p><strong>Objectives: </strong>To examine trajectories of work productivity in people living with multiple sclerosis (PwMS) and the factors associated with the trajectories.</p> <p><strong>Methods: </strong>Study participants were employed participants of the Australian MS Longitudinal Study (AMSLS) followed from 2015 to 2019 with at least two repeated measures (n=2121). We used group-based trajectory modelling to identify unique work productivity trajectories in PwMS.</p> <p><strong>Results: </strong>We identified three distinct trajectories of work productivity: 'moderately reduced' (17.0% of participants) with a mean work productivity level of 47.6% in 2015 (slope -0.97% per year (p= 0.22)), 'mildly reduced' (46.7%) with a mean work productivity of 86.3% in 2015 (slope 0.70% per year (p=0.12)), and 'full' (36.3%) with a mean work productivity of 99.7% in 2015 (slope 0.29% per year (p= 0.30)). Higher education level, higher disability, and higher MS symptom severity are associated with increased probability of being in a worse work productivity trajectory.</p> <p><strong>Conclusion: </strong>We identified three distinct work productivity trajectories in PwMS which were stable over time and differentiated by their baseline level of work productivity.</p>