Tristram 2010_blaROB-1 Presence on pB1000 in Haemophilus influenzae Is Widespread,.pdf (49.41 kB)
blaROB-1 Location on pB1000 in Haemophilus influenzae is widespread and variable cefaclor resistance is associated with altered penicillin-binding proteins
journal contributionposted on 2023-05-17, 02:58 authored by Stephen TristramStephen Tristram, Littlejohn, R, Bradbury, RS
Plasmid pB1000 is a small replicon recently identified as bearing blaROB-1 in animal and human Pasteurellaceae in Spain. We identified pB1000 in 11 blaROB-1-positive Australian and North American Haemophilus influenzae isolates, suggesting a wider role for pB1000 in disseminating blaROB-1. Native H. influenzae conjugative elements can mobilize plasmids similar to pB1000 at a low frequency of 10–8, and this might account for the infrequency of blaROB-1 compared to the rate of occurrence of blaTEM-1. Altered penicillin-binding protein 3 was associated with an increased cefaclor MIC in 3 isolates.
Publication titleAntimicrobial Agents and Chemotherapy
Department/SchoolSchool of Health Sciences
PublisherAmerican Society for Microbiology
Place of publication1752 N Street N.W. Washington DC 20036
Rights statementCopyright © 2010, American Society for Microbiology.