University of Tasmania
Browse

microRNAs are key regulators in chronic lung disease: exploring the vital link between disease progression and lung cancer

Download (202.53 kB)
journal contribution
posted on 2023-05-23, 00:20 authored by Mathew Eapen, McAlinden, KD, Stephen MyersStephen Myers, Wenying LuWenying Lu, Sukhwinder SohalSukhwinder Sohal
microRNAs (miRNAs) bind to mRNAs and inhibit their expression through post-transcriptionally regulating gene expression. Here, we elaborate upon the concise summary of the role of miRNAs in carcinogenesis with specific attention to precursor respiratory pathogenesis caused by cigarette smoke modulation of these miRNAs. We review how miRNAs are implicated in cigarette-smoke-driven mechanisms, such as epithelial to mesenchymal transition, autophagy modulation, and lung ageing, which are important in the development of chronic obstructive pulmonary disease and potential progression to lung cancer. Extracellular vesicles are key to inter-cellular communication and sharing of miRNAs. A deeper understanding of the role of miRNAs in chronic respiratory disease and their use as clinical biomarkers has great potential. Therapeutic targeting of miRNAs may significantly benefit the prevention of cancer progression.

Funding

Rebecca L Cooper Medical Research Foundation

History

Publication title

Journal of Clinical Medicine

Volume

8

Issue

11

Pagination

1-6

ISSN

2077-0383

Department/School

School of Health Sciences

Publisher

MDPI AG

Place of publication

Switzerland

Rights statement

Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC