Lin_whole_thesis_ex_pub_mat.pdf (1.74 MB)
Dissecting the genetic architecture of multiple sclerosis
thesis
posted on 2023-05-27, 12:50 authored by Lin, RMultiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) triggered by environmental and genetic factors. There is considerable evidence for a significant genetic component to MS susceptibility, such that genome-wide association studies (GWASs) have successfully revealed about 100 common genetic variants associated with MS. However, at least 60% of the overall heritability of MS has not been delineated, so-called missing heritability‚ÄövÑvp. This thesis describes a series of experiments to further elucidate the missing heritability‚ÄövÑvp of MS.
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Copyright 2014 the authorRepository Status
- Open