Pepper_whole_thesis.pdf (14.41 MB)
Oligodendrocytes modulate and maintain circuit function in the adult central nervous system
thesisposted on 2023-05-28, 12:16 authored by Pepper, RE
Within the central nervous system (CNS), cells of the oligodendrocyte lineage are critical regulators of circuit function. Oligodendrocyte progenitor cells (OPCs) generate oligodendrocytes that elaborate myelin membrane to ensheath discrete axon segments, effectively reducing axonal capacitance and enabling the saltatory conduction of action potentials. However, their role in circuit regulation does not stop there. Herein, we detail the maturation of OPCs into pre-myelinating and myelinating oligodendrocytes and outline how each cell type can influence neural network construction, operation and plasticity to ensurehealthy CNS function.
Rights statementCopyright 2020 the author Chapter 1 appears to be the equivalent of a post-print version of an article published as: Pepper, R. E., Pitman, K. A., Cullen, C. L., Young, K. M. 2018. How do cells of the oligodendrocyte lineage affect neuronal circuits to influence motor function, memory and mood?, Frontiers in cellular neuroscience, 12:399. Copyright 2018 Pepper, Pitman, Cullen and Young. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0) Chapter 2 appears to be the equivalent of a pre-print version of an article published a Cullen, C. L., Pepper, R. E., Clutterbuck, M. T., Pitman, K. A., Oorschot, V., Auderset, L., Tang, A. D., Ramm, G., Emery, B., Rodger, J., Jolivet, R. B., Young, K. M., 2021. Periaxonal and nodal plasticity modulate action potential conduction in the adult mouse brain, Cell reports, 31, 108641. Copyright 2020 the authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)