Studies into the optimisation of chronic medical therapies

Patients can vary enormously in their clinical response to drug therapy. The research presented in this thesis sought to identify specific sources of variability in therapeutic response drugs, in several clinical conditions and with several and to design and implement some measures to minimise the adverse consequences of this variability in response. The studies performed are ... 1. NIDDM study 2. Anticonvulsant compliance 3. Free phenytoin monitoring 4. Warfarin dosage prediction 5. Baclofen studies (a) Food and absorption (b) Plasma level monitoring