Studies on the chemistry of triazoles

During the last eight years a number of aspects of amide chemistry have been studied in the Chemistry Department, University of Tasmania, under the direction of Dr. J. B. Polya. Acylation of amides to diacylamines was investigated, and satisfactory syntheses were developed for unsymmetrical diacylamines (R1 .CO.NH.CO.R2; R1‚Äöv¢‚ĆR2 ). In some cases such diacylamines, through reacylation, may form mixtures of the two corresponding symmetrical diacylamines. Diacylamines react with hydrazines to form 1:2:4-triazoles, which are convenient derivatives indicating the structure of the diacylamine. With a hydrazine R.NH.NH2 an unsymmetrical diacylamine of the type indicated could form 1R-3R1 -5R2 - and 1R-3R2 -5R1 -1:2:4-triazole. Proving the orientations of the products from a number of diacylamines seemed a promising way to investigate the mechanism of this triazole synthesis.