%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Abraham Kuot, Alex W. Hewitt, Grant R. Snibson, Emmanuelle Souzeau, Richard Mills, Jamie E. Craig, Kathryn P. Burdon, Shiwani Sharma
TGC repeat expansion in the TCF4 gene increases the risk of Fuchs’ endothelial corneal dystrophy in Australian cases
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 15 0 R/Contents 16 0 R/TrimBox[0 0 612 792]>>
endobj
15 0 obj
[17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R]
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref001)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref002)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref006)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref007)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref008)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref009)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref010)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref002)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref011)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref012)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref013)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref006)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref006)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref006)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref008)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref014)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref017)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref017)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref018)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref019)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref019)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref018)>>
endobj
40 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref020)>>
endobj
41 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref021)>>
endobj
42 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref024)>>
endobj
43 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref025)>>
endobj
44 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref025)>>
endobj
45 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref026)>>
endobj
46 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref024)>>
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref027)>>
endobj
48 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref030)>>
endobj
49 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref026)>>
endobj
50 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref026)>>
endobj
51 0 obj
<>/Border[0 0 0]/Dest(Rpone.0183719.ref031)>>
endobj
52 0 obj
<>/Border[0 0 0]/A 53 0 R>>
endobj
53 0 obj
<>
endobj
16 0 obj
[54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R]
endobj
54 0 obj
<>stream
q
0.83 0.64 0.02 0 k
561.2031 706.337 m
565.9654 706.337 l
h
f*
526.3937 693.2976 m
531.1559 693.2976 l
h
f*
320.8819 667.3323 m
325.6441 667.3323 l
h
f*
321.052 641.3102 m
325.8142 641.3102 l
h
f*
446.5134 641.3102 m
451.2756 641.3102 l
h
f*
225.411 628.3276 m
230.1732 628.3276 l
h
f*
525.6 615.3449 m
530.3622 615.3449 l
h
f*
373.9465 576.3402 m
383.3575 576.3402 l
h
f*
445.3228 563.3008 m
450.0283 563.3008 l
h
f*
509.7827 550.3181 m
519.1937 550.3181 l
h
f*
531.8929 537.3354 m
541.3039 537.3354 l
h
f*
466.526 524.2961 m
475.937 524.2961 l
h
f*
453.6567 511.3134 m
458.3055 511.3134 l
h
f*
554.5701 498.3307 m
559.2189 498.3307 l
h
f*
337.9465 446.3433 m
342.652 446.3433 l
h
f*
347.0173 446.3433 m
351.7228 446.3433 l
h
f*
356.0882 446.3433 m
365.4992 446.3433 l
h
f*
370.6016 446.3433 m
380.0126 446.3433 l
h
f*
533.537 433.3039 m
542.8913 433.3039 l
h
f*
337.5496 420.3213 m
347.074 420.3213 l
h
f*
531.2693 342.3118 m
540.7937 342.3118 l
h
f*
354.5008 316.3465 m
364.0252 316.3465 l
h
f*
268.1575 290.3244 m
277.6819 290.3244 l
h
f*
491.1874 264.3024 m
500.7118 264.3024 l
h
f*
466.0157 238.337 m
475.5402 238.337 l
h
f*
480.6992 238.337 m
490.2236 238.337 l
h
f*
280.4598 225.2976 m
289.9843 225.2976 l
h
f*
471.0614 186.3496 m
480.5858 186.3496 l
h
f*
203.4142 160.3276 m
212.9386 160.3276 l
h
f*
494.9858 147.3449 m
504.5102 147.3449 l
h
f*
508.9323 147.3449 m
518.4567 147.3449 l
h
f*
523.6157 147.3449 m
533.1402 147.3449 l
h
f*
418.6205 108.3402 m
428.0882 108.3402 l
h
f*
395.8866 95.3008 m
405.3543 95.3008 l
h
f*
525.7134 95.3008 m
535.2378 95.3008 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F10 1 Tf
1 TL
-0.004 Tc
0 0 Td
(impaired)Tj
3.8437 0 Td
(ability)Tj
2.6986 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(corneal)Tj
3.1748 0 Td
(endothelium)Tj
5.3348 0 Td
(to)Tj
1.0261 0 Td
(pump)Tj
2.6022 0 Td
(excess)Tj
2.6759 0 Td
(fluid)Tj
2.0806 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(corneal)Tj
3.1747 0 Td
(stroma)Tj
3.0104 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(])Tj
-35.7786 -1.3039 Td
(which)Tj
2.6475 0 Td
(results)Tj
2.8119 0 Td
(in)Tj
1.0318 0 Td
(corneal)Tj
3.1748 0 Td
(oedema,)Tj
3.583 0 Td
(pain,)Tj
2.211 0 Td
(and)Tj
1.7291 0 Td
(ultimately)Tj
4.235 0 Td
(vision)Tj
2.6305 0 Td
(loss,)Tj
1.9162 0 Td
(if)Tj
0.7767 0 Td
(left)Tj
1.474 0 Td
(untreated)Tj
4.0762 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5987 0 Td
(Corneal)Tj
-33.8964 -1.2982 Td
(transplantation,)Tj
6.5593 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(form)Tj
2.211 0 Td
(of)Tj
1.0148 0 Td
(either)Tj
2.5285 0 Td
(penetrating)Tj
4.8189 0 Td
(or)Tj
1.0941 0 Td
(partial)Tj
2.7893 0 Td
(keratoplasty,)Tj
5.2894 0 Td
(is)Tj
0.8448 0 Td
(currently)Tj
3.8891 0 Td
(the)Tj
1.4683 0 Td
(only)Tj
-35.0076 -1.2983 Td
(effective)Tj
3.5092 0 Td
(treatment)Tj
4.1329 0 Td
(for)Tj
1.389 0 Td
(FECD)Tj
2.7155 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
-10.5504 -1.2983 Td
(The)Tj
1.7858 0 Td
(prevalence)Tj
4.4844 0 Td
(of)Tj
1.0148 0 Td
(FECD)Tj
2.7155 0 Td
(varies)Tj
2.5342 0 Td
(markedly)Tj
3.9911 0 Td
(across)Tj
2.6816 0 Td
(the)Tj
1.4683 0 Td
(world.)Tj
2.7836 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.4684 0 Td
(USA,)Tj
2.3414 0 Td
(it)Tj
0.788 0 Td
(affects)Tj
2.7383 0 Td
(~4%)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-36.1415 -1.3039 Td
(population)Tj
4.5864 0 Td
(over)Tj
1.9785 0 Td
(the)Tj
1.4684 0 Td
(age)Tj
1.542 0 Td
(of)Tj
1.0148 0 Td
(40)Tj
1.1736 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(])Tj
1.3776 0 Td
(but)Tj
1.5534 0 Td
(is)Tj
0.8447 0 Td
(less)Tj
1.61 0 Td
(frequent)Tj
3.6114 0 Td
(in)Tj
1.0374 0 Td
(Asian)Tj
2.5115 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(])Tj
1.3776 0 Td
(and)Tj
1.7292 0 Td
(Middle-Eastern)Tj
6.4629 0 Td
(popula-)Tj
-33.8794 -1.2982 Td
(tions)Tj
2.1996 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.6044 0 Td
(The)Tj
1.7802 0 Td
(prevalence)Tj
4.4843 0 Td
(has)Tj
1.5421 0 Td
(not)Tj
1.576 0 Td
(been)Tj
2.1203 0 Td
(reported)Tj
3.6624 0 Td
(in)Tj
1.0375 0 Td
(Australia)Tj
3.8437 0 Td
(but)Tj
1.5534 0 Td
(corneal)Tj
3.1691 0 Td
(grafting)Tj
3.3619 0 Td
(for)Tj
1.3833 0 Td
(FECD)Tj
-33.3182 -1.2983 Td
(accounted)Tj
4.3313 0 Td
(for)Tj
1.3889 0 Td
(~26%)Tj
2.5058 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(395\))Tj
1.9842 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(corneal)Tj
3.1691 0 Td
(grafts)Tj
2.4378 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(1533\))Tj
2.4604 0 Td
(performed)Tj
4.4731 0 Td
(in)Tj
1.0318 0 Td
(2014)Tj
2.1259 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(],)Tj
1.5988 0 Td
(indicat-)Tj
-33.8171 -1.3039 Td
(ing)Tj
1.5023 0 Td
(that)Tj
1.7745 0 Td
(the)Tj
1.4683 0 Td
(disease)Tj
3.0217 0 Td
(is)Tj
0.8447 0 Td
(relatively)Tj
3.8438 0 Td
(common.)Tj
-11.2591 -1.2983 Td
(FECD)Tj
2.7212 0 Td
(is)Tj
0.8447 0 Td
(genetically)Tj
4.4504 0 Td
(a)Tj
0.6576 0 Td
(heterogeneous)Tj
6.0264 0 Td
(disease)Tj
3.0161 0 Td
(and)Tj
1.7291 0 Td
(manifests)Tj
4.0252 0 Td
(as)Tj
1.0148 0 Td
(two)Tj
1.7064 0 Td
(forms)Tj
2.5682 0 Td
(depending)Tj
4.4674 0 Td
(upon)Tj
-0.01 Tc
-34.4237 -1.2983 Td
(the)Tj
1.4513 0 Td
(age)Tj
1.525 0 Td
(of)Tj
1.0035 0 Td
(onset.)Tj
2.5455 0 Td
(The)Tj
1.7631 0 Td
(rare,)Tj
2.0183 0 Td
(early-onset)Tj
4.5694 0 Td
(form)Tj
2.1826 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(])Tj
1.8312 0 Td
(is)Tj
0.8334 0 Td
(typically)Tj
3.5093 0 Td
(inherited)Tj
3.821 0 Td
(as)Tj
1.0035 0 Td
(an)Tj
1.1905 0 Td
(autosomal)Tj
4.303 0 Td
(dominant)Tj
-33.5506 -1.3039 Td
(disease)Tj
2.9763 0 Td
(with)Tj
1.9729 0 Td
(high)Tj
1.9842 0 Td
(penetrance)Tj
4.5695 0 Td
(and)Tj
1.7121 0 Td
(nearly)Tj
2.6645 0 Td
(uniform)Tj
3.5093 0 Td
(expressivity)Tj
4.8132 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5761 0 Td
(Mutations)Tj
4.2973 0 Td
(in)Tj
1.0261 0 Td
(the)Tj
/F15 1 Tf
1.4513 0 Td
[()-6()13()]TJ
/F10 1 Tf
-32.5528 -1.2982 Td
(\()Tj
/F15 1 Tf
[()7()10( )4( )4(\n)15()2()2(\r)]TJ
/F10 1 Tf
(,)Tj
/F15 1 Tf
3.8494 0 Td
[()-3()-13()4()]TJ
1.7971 0 Td
[()]TJ
/F10 1 Tf
(,)Tj
/F15 1 Tf
2.0693 0 Td
[(\n)11( )10()10()6(\n)]TJ
2.3811 0 Td
[()]TJ
/F10 1 Tf
(\))Tj
1.0148 0 Td
(gene)Tj
2.0523 0 Td
(account)Tj
3.3448 0 Td
(for)Tj
1.3663 0 Td
(some)Tj
2.3074 0 Td
(cases)Tj
2.194 0 Td
(of)Tj
1.0035 0 Td
(early-onset)Tj
4.5694 0 Td
(FECD)Tj
2.6929 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(];)Tj
2.0466 0 Td
(COL8A2,)Tj
-32.6889 -1.2983 Td
(an)Tj
1.1905 0 Td
(extracellular)Tj
5.0513 0 Td
(matrix)Tj
2.8403 0 Td
(protein,)Tj
3.3335 0 Td
(is)Tj
0.8334 0 Td
(a)Tj
0.6463 0 Td
(major)Tj
2.5795 0 Td
(component)Tj
4.7622 0 Td
(of)Tj
1.0034 0 Td
(the)Tj
1.4514 0 Td
(Descemet's)Tj
4.6431 0 Td
(membrane)Tj
4.5184 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.0466 0 Td
(The)Tj
-34.8999 -1.3039 Td
(more)Tj
2.3187 0 Td
(common)Tj
3.804 0 Td
(late-onset)Tj
4.0536 0 Td
(FECD)Tj
2.6929 0 Td
(typically)Tj
3.5092 0 Td
(occurs)Tj
2.795 0 Td
(after)Tj
2.0069 0 Td
(the)Tj
1.4513 0 Td
(age)Tj
1.525 0 Td
(of)Tj
1.0035 0 Td
(40)Tj
1.1622 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
1.8255 0 Td
(and)Tj
1.7121 0 Td
(can)Tj
1.6101 0 Td
(be)Tj
1.1338 0 Td
(a)Tj
0.652 0 Td
(familial)Tj
-33.2558 -1.2983 Td
(disease;)Tj
3.1917 0 Td
(the)Tj
1.4514 0 Td
(risk)Tj
1.6951 0 Td
(of)Tj
1.0034 0 Td
(the)Tj
1.4514 0 Td
(disease)Tj
2.9763 0 Td
(increases)Tj
3.7757 0 Td
(with)Tj
1.9729 0 Td
(age)Tj
1.5251 0 Td
(and)Tj
1.7121 0 Td
(female)Tj
2.8233 0 Td
(sex)Tj
1.4513 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5761 0 Td
(Familial)Tj
3.4129 0 Td
(late-onset)Tj
4.0535 0 Td
(FECD)Tj
-34.0722 -1.2982 Td
(shows)Tj
2.6305 0 Td
(an)Tj
1.1905 0 Td
(autosomal)Tj
4.2973 0 Td
(dominant)Tj
4.1272 0 Td
(inheritance)Tj
4.6885 0 Td
(with)Tj
1.9729 0 Td
(high)Tj
1.9843 0 Td
(penetrance)Tj
4.5694 0 Td
(but)Tj
1.5363 0 Td
(variable)Tj
3.3109 0 Td
(expressivity)Tj
4.8132 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
-35.121 -1.2983 Td
(Mutations)Tj
4.2972 0 Td
(in)Tj
1.0262 0 Td
(the)Tj
/F15 1 Tf
1.4513 0 Td
[()]TJ
/F10 1 Tf
2.3584 0 Td
(\()Tj
/F15 1 Tf
[()12(\r)6()-8()12(\r)13()2()2()]TJ
4.6261 0 Td
[()4()19()]TJ
2.4718 0 Td
[()11()12(\r)6()12()12(\r)13()]TJ
3.1578 0 Td
[()6()11( )6()7()13()4()19()]TJ
4.1839 0 Td
[()]TJ
/F10 1 Tf
(\),)Tj
/F15 1 Tf
1.2302 0 Td
[(!)8()14(")]TJ
/F10 1 Tf
3.8325 0 Td
(\()Tj
/F15 1 Tf
[(#)-3()10( )12($)14()11()]TJ
2.7666 0 Td
[()7(\n)16()-9()-9()4()2()]TJ
2.7779 0 Td
[()9(\n)16( )18()4( )15()]TJ
2.6532 0 Td
[(")]TJ
/F10 1 Tf
(,)Tj
/F15 1 Tf
-36.8331 -1.3039 Td
[(#)-3()4()12()12($)12( )]TJ
3.0443 0 Td
[()4()11()20(\n)22()11()]TJ
2.6646 0 Td
[()7()20(\n)16(\r#)10()4()11()-19()11()2()]TJ
/F10 1 Tf
(,)Tj
/F15 1 Tf
4.7281 0 Td
[( )6()2( )17()4()2()]TJ
3.3619 0 Td
[()]TJ
/F10 1 Tf
(\),)Tj
/F15 1 Tf
1.6951 0 Td
[()14()20(%&')]TJ
/F10 1 Tf
3.9345 0 Td
(\()Tj
/F15 1 Tf
[( )12()10()4()19()-3()2()2(\r)6(\n#)-3()]TJ
5.3631 0 Td
[()6()11( )6()10( )4()2()-21()]TJ
3.9345 0 Td
[()4()11( )6(\n)16()12(\r#)]TJ
3.5319 0 Td
[()]TJ
/F10 1 Tf
(\))Tj
1.0091 0 Td
(and)Tj
/F15 1 Tf
-33.2671 -1.2983 Td
[()35(\()]TJ
/F10 1 Tf
3.0784 0 Td
(\()Tj
/F15 1 Tf
[()89(\)*+\(\)*)]TJ
4.422 0 Td
[()11()12(\r)6()12()12(\r)13()]TJ
3.1578 0 Td
[()11()20()12()11()2()12(\r )12()4(,)8()]TJ
4.6261 0 Td
[()]TJ
/F10 1 Tf
(\))Tj
1.0091 0 Td
(genes)Tj
2.4151 0 Td
(cause)Tj
2.3584 0 Td
(the)Tj
1.4513 0 Td
(late-onset)Tj
4.0536 0 Td
(disease)Tj
2.9706 0 Td
(in)Tj
1.0262 0 Td
(a)Tj
0.6463 0 Td
(small)Tj
2.296 0 Td
(number)Tj
-33.5109 -1.2983 Td
(of)Tj
1.0034 0 Td
(familial,)Tj
3.3902 0 Td
(and/or)Tj
2.9027 0 Td
(unrelated)Tj
3.9685 0 Td
(cases)Tj
2.194 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2415 0 Td
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
0.9071 0 Td
(14)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
3.1635 0 Td
(Additionally,)Tj
5.3801 0 Td
(four)Tj
1.8878 0 Td
(chromosomal)Tj
5.6806 0 Td
(loci)Tj
1.6385 0 Td
(have)Tj
2.0352 0 Td
(been)Tj
-35.3931 -1.3039 Td
(linked)Tj
2.6928 0 Td
(with)Tj
1.9729 0 Td
(familial)Tj
3.1748 0 Td
(late-onset)Tj
4.0479 0 Td
(disease)Tj
2.9763 0 Td
(but)Tj
1.5364 0 Td
(the)Tj
1.4513 0 Td
(causative)Tj
3.7928 0 Td
(genes)Tj
2.4094 0 Td
(are)Tj
1.4343 0 Td
(yet)Tj
1.3777 0 Td
(to)Tj
1.0091 0 Td
(be)Tj
1.1395 0 Td
(identified)Tj
4.0025 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
-0.004 Tc
-31.8215 -1.2982 Td
(In)Tj
1.1111 0 Td
(2010,)Tj
2.3471 0 Td
(Baratz)Tj
2.7496 0 Td
(and)Tj
1.7348 0 Td
(colleagues)Tj
4.2746 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(],)Tj
2.075 0 Td
(through)Tj
3.4469 0 Td
(a)Tj
0.6519 0 Td
(genome-wide)Tj
5.6636 0 Td
(association)Tj
4.6261 0 Td
(study)Tj
2.3925 0 Td
(\(GWAS\))Tj
3.7417 0 Td
(in)Tj
-36.0111 -1.2983 Td
(white)Tj
2.4151 0 Td
(American)Tj
4.1839 0 Td
(cases,)Tj
2.4434 0 Td
(reported)Tj
3.6567 0 Td
(a)Tj
0.6519 0 Td
(highly)Tj
2.7043 0 Td
(significant)Tj
4.3823 0 Td
(association)Tj
4.6205 0 Td
(between)Tj
3.5262 0 Td
(single)Tj
2.5285 0 Td
(nucleotide)Tj
4.405 0 Td
(poly-)Tj
-35.5178 -1.3039 Td
(morphisms)Tj
4.7621 0 Td
(\(SNPs\))Tj
3.0274 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
/F15 1 Tf
1.4627 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4094 0 Td
(\()Tj
/F15 1 Tf
[(\))75()20(\n)16(\r#)-3()1()-9()10()12()7()4()11(\r)]TJ
5.8847 0 Td
[()9(\n)6()-4()11()11()]TJ
2.4605 0 Td
[(")]TJ
/F10 1 Tf
(\))Tj
1.0204 0 Td
(gene)Tj
2.075 0 Td
(and)Tj
1.7234 0 Td
(late-onset)Tj
4.1046 0 Td
(FECD;)Tj
2.9366 0 Td
(the)Tj
1.4627 0 Td
(intronic)Tj
-34.3613 -1.2983 Td
(SNP)Tj
1.9899 0 Td
(rs613872)Tj
3.804 0 Td
(was)Tj
1.7008 0 Td
(the)Tj
1.4683 0 Td
(most)Tj
2.2054 0 Td
(significantly)Tj
5.091 0 Td
(associated)Tj
4.2576 0 Td
(variant.)Tj
3.2541 0 Td
(Recently,)Tj
3.8835 0 Td
(our)Tj
1.6271 0 Td
(collaborative)Tj
5.3404 0 Td
(group)Tj
-34.6221 -1.2983 Td
(through)Tj
3.4412 0 Td
(GWAS)Tj
3.0614 0 Td
(identified)Tj
4.0592 0 Td
(genome-wide)Tj
5.6636 0 Td
(significant)Tj
4.388 0 Td
(association)Tj
4.6261 0 Td
(of)Tj
1.0148 0 Td
(SNPs)Tj
2.3527 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
/F15 1 Tf
1.4683 0 Td
[(.)4(/.")]TJ
/F10 1 Tf
3.3165 0 Td
(\()Tj
/F15 1 Tf
[(./)]TJ
-34.4293 -1.2982 Td
[( )6()12()7()12()]TJ
2.6248 0 Td
[(\n)16(\r)6()]TJ
1.7291 0 Td
[(\n)16(\r)10(,)16()-13()-9()12(\r)]TJ
3.2882 0 Td
[()20()2()4()7(\n)22()]TJ
2.6249 0 Td
[()4()11( )6(\n)16()12(\r)7()11(\r)22()11(\n)16()12(\r)18()12(\r)13()]TJ
7.7215 0 Td
[()11()20()12()11()2()12(\r)]TJ
3.0104 0 Td
[(")]TJ
/F10 1 Tf
(\))Tj
1.0261 0 Td
(and)Tj
/F15 1 Tf
1.7291 0 Td
[()-13(0)15()]TJ
/F10 1 Tf
3.3562 0 Td
(\()Tj
/F15 1 Tf
[()-3(\n)16( )18()12(\r)18()12(\r)]TJ
3.9458 0 Td
[()2(\n)16( )18( )6(\n)]TJ
/F10 1 Tf
(\),)Tj
4.5184 0 Td
(and)Tj
-35.5745 -1.3039 Td
(near)Tj
/F15 1 Tf
1.9955 0 Td
[()89(\)*)]TJ
/F10 1 Tf
3.515 0 Td
(\()Tj
/F15 1 Tf
[(/)28(\n1)]TJ
/F10 1 Tf
(,)Tj
/F15 1 Tf
2.5511 0 Td
[(.1)]TJ
1.457 0 Td
[()7()20(\n)16(\r#)10()4()11()-19()7()12(\r)13()]TJ
5.0287 0 Td
[()89(\)*)23(\n#)-3()]TJ
/F10 1 Tf
(,)Tj
/F15 1 Tf
3.4469 0 Td
[()4()8()11(\n)]TJ
2.6645 0 Td
[()4()10( )15()-13()4()2()12()7()4()4()]TJ
/F10 1 Tf
(\))Tj
4.972 0 Td
(genes)Tj
2.4377 0 Td
(with)Tj
2.0013 0 Td
(FECD)Tj
2.7156 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(])Tj
1.8481 0 Td
(and)Tj
-34.6334 -1.2983 Td
(revealed)Tj
3.5206 0 Td
(three)Tj
2.2677 0 Td
(additional)Tj
4.2746 0 Td
(loci)Tj
1.6667 0 Td
(involved)Tj
3.651 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4741 0 Td
(disease.)Tj
3.2428 0 Td
(However,)Tj
4.0762 0 Td
(the)Tj
/F15 1 Tf
1.4683 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4151 0 Td
(locus)Tj
2.2847 0 Td
(remains)Tj
3.4469 0 Td
(the)Tj
-34.8205 -1.2983 Td
(strongest)Tj
3.855 0 Td
(associated)Tj
4.252 0 Td
(locus)Tj
2.2904 0 Td
(with)Tj
1.9955 0 Td
(FECD)Tj
2.7156 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(].)Tj
-13.9123 -1.3039 Td
(The)Tj
/F15 1 Tf
1.7858 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4151 0 Td
(gene)Tj
2.0806 0 Td
(is)Tj
0.8447 0 Td
(located)Tj
3.0841 0 Td
(on)Tj
1.2756 0 Td
(chromosome)Tj
5.4821 0 Td
(18)Tj
1.1736 0 Td
(and)Tj
1.7291 0 Td
(codes)Tj
2.4661 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(helix-loop-helix)Tj
6.5593 0 Td
(transcrip-)Tj
-32.944 -1.2982 Td
(tion)Tj
1.8425 0 Td
(factor)Tj
2.5398 0 Td
(E2-2)Tj
2.0919 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.075 0 Td
(Our)Tj
1.8652 0 Td
(group,)Tj
2.8346 0 Td
(through)Tj
3.4469 0 Td
(an)Tj
1.2019 0 Td
(independent)Tj
5.2724 0 Td
(replication)Tj
4.5241 0 Td
(study,)Tj
2.6135 0 Td
(reported)Tj
3.6623 0 Td
(the)Tj
1.4684 0 Td
(asso-)Tj
-35.4385 -1.2983 Td
(ciation)Tj
2.965 0 Td
(of)Tj
1.0148 0 Td
(SNPs)Tj
2.3527 0 Td
(in)Tj
/F15 1 Tf
1.0318 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4151 0 Td
(with)Tj
2.0013 0 Td
(advanced)Tj
3.9911 0 Td
(FECD)Tj
2.7156 0 Td
(in)Tj
1.0375 0 Td
(white)Tj
2.4207 0 Td
(Australians,)Tj
4.9776 0 Td
(which)Tj
2.6533 0 Td
(demonstrated)Tj
5.7599 0 Td
(the)Tj
-35.3364 -1.3039 Td
(contribution)Tj
5.2894 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(gene)Tj
2.0806 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4741 0 Td
(disease)Tj
3.016 0 Td
(risk)Tj
1.7121 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(Australian)Tj
4.3937 0 Td
(population)Tj
4.5921 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(].)Tj
2.0749 0 Td
(Similar)Tj
3.1011 0 Td
(indepen-)Tj
-33.9531 -1.2983 Td
(dent)Tj
2.0182 0 Td
(studies)Tj
2.9877 0 Td
(by)Tj
1.1792 0 Td
(other)Tj
2.3471 0 Td
(groups)Tj
2.9707 0 Td
(have)Tj
2.0579 0 Td
(shown)Tj
2.8516 0 Td
(association)Tj
4.6262 0 Td
(of)Tj
1.0148 0 Td
(SNPs,)Tj
2.5795 0 Td
(mainly)Tj
2.9877 0 Td
(rs613872,)Tj
4.0308 0 Td
(in)Tj
/F15 1 Tf
1.0375 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4151 0 Td
(with)Tj
-35.104 -1.2983 Td
(advanced)Tj
3.9911 0 Td
(FECD)Tj
2.7156 0 Td
(including)Tj
4.0422 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(Indian)Tj
2.8856 0 Td
(and)Tj
1.7348 0 Td
(Chinese)Tj
3.4299 0 Td
(populations)Tj
4.9549 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
3.5433 0 Td
(Subsequently,)Tj
5.7487 0 Td
(Wie-)Tj
-35.5519 -1.3039 Td
(ben)Tj
1.6951 0 Td
(and)Tj
1.7347 0 Td
(colleagues)Tj
4.2747 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(])Tj
1.8538 0 Td
(identified)Tj
4.0592 0 Td
(a)Tj
0.652 0 Td
(significant)Tj
4.388 0 Td
(association)Tj
4.6261 0 Td
(of)Tj
1.0148 0 Td
(thymine-guanine-cyt)Tj
8.4358 0 Td
(osine)Tj
-32.7342 -1.2982 Td
(\(TGC\))Tj
2.8913 0 Td
(repeat)Tj
2.6872 0 Td
(expansion)Tj
4.2916 0 Td
(in)Tj
1.0318 0 Td
(intron)Tj
2.761 0 Td
(3)Tj
0.6973 0 Td
(of)Tj
/F15 1 Tf
1.0148 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4151 0 Td
(with)Tj
1.9956 0 Td
(FECD)Tj
2.7212 0 Td
(in)Tj
1.0318 0 Td
(white)Tj
2.4208 0 Td
(Americans)Tj
4.5524 0 Td
(and)Tj
1.7291 0 Td
(reported)Tj
3.6623 0 Td
(the)Tj
-35.9033 -1.2983 Td
(repeat)Tj
2.6872 0 Td
(expansion)Tj
4.2916 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(a)Tj
0.652 0 Td
(stronger)Tj
3.5659 0 Td
(predictor)Tj
3.9288 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(disease)Tj
3.016 0 Td
(than)Tj
2.0296 0 Td
(SNP)Tj
1.9899 0 Td
(rs613872;)Tj
4.0308 0 Td
(repeat)Tj
2.6929 0 Td
(lengths)Tj
3.0898 0 Td
(of)Tj
/F16 1 Tf
0 Tc
-36.6347 -1.2983 Td
(>)Tj
/F10 1 Tf
-0.004 Tc
(50)Tj
1.9388 0 Td
(were)Tj
2.1147 0 Td
(found)Tj
2.6135 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1452 0 Td
(more)Tj
2.3358 0 Td
(frequent)Tj
3.6056 0 Td
(in)Tj
1.0261 0 Td
(cases)Tj
2.2224 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0205 0 Td
(controls)Tj
3.4752 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
2.075 0 Td
(The)Tj
/F15 1 Tf
1.7744 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4095 0 Td
(TGC)Tj
2.2053 0 Td
(trinu-)Tj
-35.2287 -1.3039 Td
(cleotide)Tj
3.3335 0 Td
(repeat)Tj
2.6872 0 Td
(was)Tj
1.7008 0 Td
(first)Tj
1.8085 0 Td
(identified)Tj
4.0592 0 Td
(by)Tj
1.1792 0 Td
(Breschel)Tj
3.5773 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1281 0 Td
(in)Tj
1.0318 0 Td
(1997)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(named)Tj
2.9707 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(CTG18.1)Tj
3.8608 0 Td
(locus)Tj
-34.6221 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
2.0749 0 Td
(Association)Tj
4.8812 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6725 0 Td
(repeat)Tj
2.6872 0 Td
(expansion)Tj
4.2916 0 Td
(in)Tj
/F15 1 Tf
1.0375 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4151 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(disease)Tj
3.016 0 Td
(has)Tj
1.5478 0 Td
(been)Tj
2.1203 0 Td
(replicated)Tj
4.1498 0 Td
(since)Tj
2.2451 0 Td
(in)Tj
-36.6177 -1.2982 Td
(independent)Tj
5.2724 0 Td
(white)Tj
2.4207 0 Td
(American,)Tj
4.4164 0 Td
(Indian,)Tj
3.1124 0 Td
(Chinese)Tj
3.4356 0 Td
(and)Tj
1.7291 0 Td
(Japanese)Tj
3.6907 0 Td
(case)Tj
1.8652 0 Td
(cohorts)Tj
3.2144 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(27)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(];)Tj
3.2088 0 Td
(TGC)Tj
-34.1005 -1.3039 Td
(repeat)Tj
2.6872 0 Td
(length)Tj
2.7269 0 Td
(of)Tj
/F8 1 Tf
0 Tc
1.0148 0 Td
()Tj
/F10 1 Tf
-0.004 Tc
(40)Tj
1.9445 0 Td
(was)Tj
1.7008 0 Td
(associated)Tj
4.2576 0 Td
(in)Tj
1.0318 0 Td
(these)Tj
2.2564 0 Td
(populations.)Tj
5.176 0 Td
(This)Tj
1.9843 0 Td
(cut-off)Tj
2.9083 0 Td
(is)Tj
0.8447 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(initial)Tj
-33.7547 -1.2983 Td
(discovery)Tj
4.0081 0 Td
(that)Tj
1.7745 0 Td
(indicated)Tj
3.9401 0 Td
(that)Tj
1.7745 0 Td
(expansion)Tj
4.2916 0 Td
(of)Tj
1.0092 0 Td
(the)Tj
1.4683 0 Td
(TGC)Tj
2.211 0 Td
(repeat)Tj
2.6872 0 Td
(locus)Tj
2.2847 0 Td
(in)Tj
1.0318 0 Td
(3%)Tj
1.4514 0 Td
(of)Tj
1.0148 0 Td
(subjects)Tj
3.3732 0 Td
(in)Tj
1.0375 0 Td
(white)Tj
2.4151 0 Td
(ped-)Tj
-35.773 -1.2983 Td
(igrees)Tj
2.5284 0 Td
(was)Tj
1.7008 0 Td
(not)Tj
1.5761 0 Td
(associated)Tj
4.2519 0 Td
(with)Tj
2.0013 0 Td
(any)Tj
1.6554 0 Td
(known)Tj
3.0047 0 Td
(phenotypes)Tj
4.8018 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(])Tj
1.8482 0 Td
(whereas)Tj
3.4469 0 Td
(the)Tj
1.4684 0 Td
(expanded)Tj
4.0875 0 Td
(alleles)Tj
2.6022 0 Td
(with)Tj
-34.9736 -1.3039 Td
(repeat)Tj
2.6872 0 Td
(lengths)Tj
/F16 1 Tf
0 Tc
3.0897 0 Td
(>)Tj
/F10 1 Tf
-0.004 Tc
(37)Tj
1.9446 0 Td
(were)Tj
2.1203 0 Td
(reported)Tj
3.6623 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1451 0 Td
(unstable)Tj
3.5717 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
2.0749 0 Td
(Additionally,)Tj
5.4538 0 Td
(Mootha)Tj
3.3846 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1282 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(])Tj
1.8538 0 Td
(found)Tj
-34.0835 -1.2982 Td
(segregation)Tj
4.7848 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(expanded)Tj
4.0876 0 Td
(TGC)Tj
2.211 0 Td
(repeats)Tj
3.05 0 Td
(in)Tj
/F15 1 Tf
1.0318 0 Td
[(\))-5(-")]TJ
/F10 1 Tf
2.4151 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(disease)Tj
3.0161 0 Td
(in)Tj
1.0374 0 Td
(several)Tj
2.9311 0 Td
(affected)Tj
3.3278 0 Td
(families)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 311.8677 745.7952 cm
BT
/F7 1 Tf
1 TL
-0.005 Tc
0 0 Td
(TCF4)Tj
/F0 1 Tf
2.6929 0 Td
(TGC)Tj
2.3102 0 Td
(repeat)Tj
3.0048 0 Td
(expansion)Tj
4.6914 0 Td
(associates)Tj
4.8614 0 Td
(with)Tj
1.963 0 Td
(FECD)Tj
2.9126 0 Td
(susceptibility)Tj
5.7828 0 Td
(in)Tj
0.9779 0 Td
(Austral)Tj
3.0544 0 Td
(ia)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01837)Tj
4.089 0 Td
(19)Tj
0 g
2.0906 0 Td
(August)Tj
3.2882 0 Td
(23,)Tj
1.5874 0 Td
(2017)Tj
34.0302 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(13)Tj
/F12 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(collection)Tj
3.7417 0 Td
(and)Tj
1.5874 0 Td
(analysis)Tj
2.9623 0 Td
(,)Tj
0.4464 0 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
-16.1221 -1.3748 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F11 1 Tf
-6.7606 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F12 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3749 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
endstream
endobj
65 0 obj
<>stream
endstream
endobj
66 0 obj
<>stream
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
BT
10.3394 79.2147 Td
(exist.)Tj
ET
Q
endstream
endobj
78 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 14 0 R/Annots 83 0 R/Contents 84 0 R/TrimBox[0 0 612 792]>>
endobj
80 0 obj
<>
endobj
85 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
9 beginbfchar
<000F><002C>
<0010><002D>
<0016><0033>
<0018><0035>
<0024><0041>
<0026><0043>
<002A><0047>
<0037><0054>
<00B6><2019>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
86 0 obj
<>/FontDescriptor 87 0 R/DW 600>>
endobj
87 0 obj
<>
endobj
88 0 obj
<>stream
cvt a &@ fpgm62 h glyf$Q 8 head\t 6hhea{<