University Of Tasmania
Zhu 2017 OAC7026 XS Longitudinal associations serum cytokins and knee BMLs.docx (145.36 kB)
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Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis

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journal contribution
posted on 2023-05-19, 00:26 authored by Zhu, Z, Petr OtahalPetr Otahal, Wang, B, Jin, X, Laura LaslettLaura Laslett, Wluka, AE, Benny Eathakkattu AntonyBenny Eathakkattu Antony, Han, W, Wang, X, Tania WinzenbergTania Winzenberg, Cicuttini, F, Graeme JonesGraeme Jones, Chang-Hai DingChang-Hai Ding
OBJECTIVE: To describe cross-sectional and longitudinal associations between serum levels of interleukin (IL) - 6, IL-17A, IL-17F, IL-23 and knee bone marrow lesions (BMLs) in patients with knee osteoarthritis (OA).

DESIGN: Patients (n = 192) with symptomatic knee OA (mean 63 years, range 50-79, female 53%) were assessed at baseline and after 24 months. At each time point, serum IL-6, IL-17A, IL-17F and IL-23 were measured using Bio-Plex® Multiplex Immunoassays with Luminex xMAP technology. Knee BMLs were scored using the modified whole organ MRI score (WORMS) from T2 weighted fat-suppressed fast spin echo magnetic resonance imaging (MRI). Multivariable linear regression and log binominal regression were used to determine the associations between cytokines and BMLs.

RESULTS: Baseline IL-6 (quarters) were significantly associated with total knee BMLs (P < 0.01 for the trend) as well as associated with an increase in BML score (P = 0.05 for the trend), after adjustment for confounders. Baseline IL-17F and IL-23 (highest quarters vs others) was associated with an increase in BML score in females (P = 0.04 for IL-17F; P = 0.01 for IL-23), but not in males, in multivariable analyses. In contrast, IL-17A was not significantly associated with BMLs in either females or males.

CONCLUSION: IL-6 is associated with increased knee BMLs in both females and males with OA. Serum IL-17F and IL-23 predicted increased knee BML scores in females only, suggesting that inflammation is involved in BML pathogenesis in knee OA, especially in women.


Publication title

Osteoarthritis and Cartilage










Menzies Institute for Medical Research


Elsevier Ltd

Place of publication

United Kingdom

Rights statement

Copyright 2016 Osteoarthritis Research Society International

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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