134789 - Haemopedia.pdf (2.61 MB)
Haemopedia: an expression atlas of murine hematopoietic cells
journal contributionposted on 2023-05-20, 06:53 authored by de Graaf, CA, Choi, J, Baldwin, TM, Bolden, JE, Kirsten FairfaxKirsten Fairfax, Robinson, AJ, Biben, C, Morgan, C, Ramsay, K, Ng, AP, Kauppi, M, Kruse, EA, Sargeant, TJ, Seidenman, N, D'Amico, A, D'Ombrain, MC, Lucas, EC, Koernig, S, Baz Morelli, A, Wilson, MJ, Dower, SK, Williams, B, Heazlewood, SY, Hu, Y, Nilsson, SK, Wu, L, Smyth, GK, Alexander, WS, Hilton, DJ
Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. We include rare cell populations such as eosinophils, mast cells, basophils, and megakaryocytes, and a broad collection of progenitor and stem cells. We show that lineage branching and maturation during hematopoiesis can be reconstructed using the expression patterns of small sets of genes. We also have identified genes with enriched expression in each of the mature blood cell lineages, many of which show conserved lineage-enriched expression in human hematopoiesis. We have created an online web portal called Haemosphere to make analyses of Haemopedia and other blood cell transcriptional datasets easier. This resource provides simple tools to interrogate gene-expression-based relationships between hematopoietic cell types and genes of interest.
Publication titleStem Cell Reports
Department/SchoolMenzies Institute for Medical Research
Place of publicationUnited States
Rights statementCopyright 2016 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).