92204 Journal Article.pdf (397.95 kB)
Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease
journal contributionposted on 2023-05-18, 01:22 authored by Dawkins, E, David SmallDavid Small
The Î²-amyloid precursor protein (APP) has been extensively studied for its role as the precursor of the Î²-amyloid protein (AÎ²) of Alzheimer's disease. However, the normal function of APP remains largely unknown. This article reviews studies on the structure, expression and post-translational processing of APP, as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms. Â© 2014 The Authors.
Publication titleJournal of Neurochemistry
Department/SchoolMenzies Institute for Medical Research
PublisherBlackwell Publishing Ltd
Place of publication9600 Garsington Rd, Oxford, England, Oxon, Ox4 2Dg
Rights statementCopyright 2014 The Authors-This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, (CC BY-NC-ND 2.0 AU) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modi!cations or adaptations are made.