University Of Tasmania
Rivers-Auty et al. 2018 Nat. Comms.pdf (896.71 kB)
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Redefining the ancestral origins of the interleukin-1 superfamily

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posted on 2023-05-20, 08:22 authored by Jack AutyJack Auty, Daniels, MJD, Colliver, I, Roberston, DL, Brough, D
The interleukin-1 (IL-1) receptor and ligand families are components of the immune system. Knowledge of their evolutionary history is essential to understand their function. Using chromosomal anatomy and sequence similarity, we show that IL-1 receptor family members are related and nine members are likely formed from duplication and modification of a proto-IL-1R1 receptor. The IL-1 ligands have a different evolutionary history. The first proto-IL-1β gene coincided with proto-IL-1R1 and duplication events resulted in the majority of IL-1 ligand family members. However, large evolutionary distances are observed for IL-1α, IL-18 and IL-33 proteins. Further analysis show that IL-33 and IL-18 have poor sequence similarity and no chromosomal evidence of common ancestry with the IL-1β cluster and therefore should not be included in the IL-1 ligand ancestral family. IL-1α formed from the duplication of IL-1β, and moonlighting functions of pro-IL-1α acted as divergent selection pressures for the observed sequence dissimilarity.


Publication title

Nature Communications








Tasmanian School of Medicine


Nature Publishing Group

Place of publication

United Kingdom

Rights statement

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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  • Open

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Expanding knowledge in the biological sciences

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