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149235 - Sensory stimulation for apnoea mitigation in preterm infants_OA.pdf (128.05 kB)

Sensory stimulation for apnoea mitigation in preterm infants

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posted on 2023-05-21, 06:25 authored by Kai LimKai Lim, Cramer, SJE, te Pas, AB, Timothy GaleTimothy Gale, Peter DargavillePeter Dargaville
Apnoea, a pause in respiration, is ubiquitous in preterm infants and are often associated with physiological instability, which may lead to longer-term adverse neurodevelopmental consequences. Despite current therapies aimed at reducing the apnoea burden, preterm infants continue to exhibit apnoeic events throughout their hospital admission. Bedside staff are frequently required to manually intervene with different forms of stimuli, with the aim of re-establishing respiratory cadence and minimizing the physiological impact of each apnoeic event. Such a reactive approach makes apnoea and its associated adverse consequences inevitable and places a heavy reliance on human intervention. Different approaches to improving apnoea management in preterm infants have been investigated, including the use of various sensory stimuli. Despite studies reporting sensory stimuli of various forms to have potential in reducing apnoea frequency, non-invasive intermittent positive pressure ventilation is the only automated stimulus currently used in the clinical setting for infants with persistent apnoeic events. We find that the development of automated closed-looped sensory stimulation systems for apnoea mitigation in preterm infants receiving non-invasive respiratory support is warranted, including the possibility of stimulation being applied preventatively, and in a multi-modal form.


Publication title

Pediatric Research






Menzies Institute for Medical Research


Int Pediatric Research Foundation

Place of publication

Inc, 351 West Camden St, Baltimore, USA, Md, 21201-2436

Rights statement

Copyright The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc

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  • Restricted

Socio-economic Objectives

Treatment of human diseases and conditions

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